EMID1, a multifunctional molecule identified in a murine model for the invasion independent metastasis pathway

Abstract EMI Domain Containing 1 (EMID1) was identified as a potential candidate metastasis-promoting gene. We sought to clarify the molecular function of EMID1 and protein expression. Overexpression knockdown studies using mouse tumor cell lines two novel functions EMID1: intracellular signaling involving enhancement growth via cycle promotion suppression motility, inhibition cell–matrix adhesion by extracellularly secreted EMID1. deposited on culture dish induced self-detachment cells that overexpressed inhibited additionally seeded cells. This multifunctional property both extracellular matrix suggests may be matricellular proteins. Expression analysis immunohistochemical staining revealed expression limited chief gastric fundic gland β pancreatic islets in normal adult human tissues, implying cell-specific this molecule. In addition, increased detected some cases cancers implies might new therapeutic target for cancer treatment.